Company
Company
Core Technology & Patents
Core Technology & Patents
OEM/ODM
OEM/ODM
About Dr's VIEW
About Dr's VIEW
GREEN HEALING NATURAL SUPPLEMENTS
Medience Co., Ltd. is a leading company that contributes to human health
and pioneers the healthcare industry through products developed from natural sources.
GREEN HEALING NATURAL SUPPLEMENTS
We proudly specialize in developing natural ingredients and
conducting innovative new drug research to promote healthy longevity and enhance human happiness.
GREEN HEALING NATURAL SUPPLEMENTS
Through our brand, Dr's VIEW, which is dedicated to promoting a healthier life in harmony with nature,
Medience Co., Ltd. delivers its technology and values to you.
GREEN HEALING NATURAL SUPPLEMENTS
By leveraging natural resources across all fields—including food, health supplements,
and new drug development—we pledge to fulfill our social responsibilities as a trusted healthcare innovator.
GREEN HEALING
NATURAL SUPPLEMENTS
Medience Co., Ltd. is a leading company that contributes to human health and
pioneers the healthcare industry through products developed from natural sources.
GREEN HEALING
NATURAL SUPPLEMENTS
We proudly specialize in developing natural ingredients and conducting innovative new drug research to promote healthy longevity and enhance human happiness.
GREEN HEALING
NATURAL SUPPLEMENTS
Through our brand, Dr's VIEW, which is dedicated to promoting a healthier life in harmony with nature, Medience Co., Ltd. delivers its technology and values to you.
GREEN HEALING
NATURAL SUPPLEMENTS
By leveraging natural resources across all fields—including food, health supplements, and new drug development—we pledge to fulfill our social responsibilities as a trusted healthcare innovator.
Company
Core Technology & Patents
OEM/ODM
About Dr's VIEW
Mission & Vision
Mission
A technology-driven company dedicated to harmonizing with nature
Mission
A technology-driven company dedicated to harmonizing with nature
Vision
A global leader in life science, dedicated to advancing human health and well-being
Vision
A global leader in life science, dedicated to advancing human health and well-being
Core Value
R&D
Medience aims for sustainable health for humanity, developing technologies with top-tier experts across various fields
NATURAL EXTRACT
Medience performs extraction, concentration, separation, and purification of various natural sources to isolate active components. Through our premium functional dietary supplement brand, Dr's VIEW, we deliver these scientifically validated products to consumers with the highest quality standards.
FLAVONOID EXTRACTION
Flavonoids, found in most plants, have antioxidant effects and diverse bioactivities, contributing to the rapid growth of the global functional ingredient market. Medience leads this field by applying advanced analysis, production, separation, and purification techniques to develop premium functional ingredients.
FERMENTATION TECHNOLOGY
Fermentation promotes the production of beneficial compounds through microorganisms while reducing harmful substances. Demand is also growing for products designed to improve metabolism and enhance bioavailability. Medience owns proprietary Korean Lactobacillus sp. strains and produces high-efficiency GABA-rich fermented materials, applying them across diverse biotransformation processes.
COMMERCIALIZATION SERVICES
Medience provides A-to-Z commercialization services for individually recognized ingredients with proven functionality, based on 24 years of R&D expertise. Our services cover marker compound development, analysis, process establishment, scale-up, economic analysis, clinical trials, patent and stability asset protection, ensuring competitive and high-value product development.
ENGINEERING
With over 24 years of accumulated expertise in food-related R&D, process development, and plant construction, Medience offers comprehensive engineering solutions for the development of health functional food production processes and facility construction. Process efficiency is a critical factor in the success of any manufacturing plant. We possess extensive experience in developing production processes and constructing factories for diverse materials such as Y-PEP (egg yolk lecithin), AGK (Angelica gigas Nakai extract), ISD (herbal extracts), and other natural sources.
Products
Partnership
History
For Humanity, Medience Moves Forward Without Ceasing
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Contents
For sustainable health, Medience is opening the future at this very moment
Mediance Co., Ltd. participated as an official sponsor of the 2025 Uiseong Cheonhajangsa Ssireum Festival, held from November 23 to 29, 2025, by providing its proprietary cognitive health supplement, Tteoolla AO300. Tteoolla AO300 is a functional health supplement designed to support cognitive enhancement, featuring a distinctive double-formula structure that combines ingredients known to help improve memory with premium Korean red ginseng. The product also supports immune function, making it suitable for a wide range of consumers. Through this sponsorship, Mediance aimed to highlight the scientific excellence and brand value of Tteoolla AO300, while providing healthy energy to the athletes and spectators participating in the festival. Mediance will continue to expand its brand presence by engaging in various sports and community activities, reinforcing the company’s commitment to enhancing customer well-being and delivering high-quality health functional products.
Mediance Sponsors “2025 Uiseong Cheonhajangsa Ssireum Festival” with Tteoolla AO300Mediance Co., Ltd. participated as an official sponsor of the 2025 Uiseong Cheonhajangsa Ssireum Festival, held from November 23 to 29, 2025, by providing its proprietary cognitive health supplement, Tteoolla AO300. Tteoolla AO300 is a functional health supplement designed to support cognitive enhancement, featuring a distinctive double-formula structure that combines ingredients known to help improve memory with premium Korean red ginseng. The product also supports immune function, making it suitable for a wide range of consumers. Through this sponsorship, Mediance aimed to highlight the scientific excellence and brand value of Tteoolla AO300, while providing healthy energy to the athletes and spectators participating in the festival. Mediance will continue to expand its brand presence by engaging in various sports and community activities, reinforcing the company’s commitment to enhancing customer well-being and delivering high-quality health functional products.
Mediance Co., Ltd. has recently signed a Memorandum of Understanding (MOU) with Korea Park Golf Co., Ltd. to jointly promote the sales of health supplements. Korea Park Golf is a leading company in the domestic park golf industry, holding approximately 70% market share and operating a strong nationwide network of dealerships and infrastructure. Through this agreement, the two companies will establish a strategic collaboration in which Mediance develops and manufactures health functional products, while Korea Park Golf utilizes its distribution channels to deliver them to market. Under this MOU, the two companies plan to pursue various forms of cooperation, including: Planning and manufacturing high-quality health functional supplements Joint development of products tailored specifically for the park golf market Activation of nationwide product distribution through Korea Park Golf’s sales channels Through this partnership, Mediance aims to expand its customer base and strengthen the competitiveness of its health supplement business. Both companies expect to create significant long-term synergy based on this strategic alliance.
Mediance Signs MOU with Korea Park Golf Co., Ltd. for Health Supplement Sales CollaborationMediance Co., Ltd. has recently signed a Memorandum of Understanding (MOU) with Korea Park Golf Co., Ltd. to jointly promote the sales of health supplements. Korea Park Golf is a leading company in the domestic park golf industry, holding approximately 70% market share and operating a strong nationwide network of dealerships and infrastructure. Through this agreement, the two companies will establish a strategic collaboration in which Mediance develops and manufactures health functional products, while Korea Park Golf utilizes its distribution channels to deliver them to market. Under this MOU, the two companies plan to pursue various forms of cooperation, including: Planning and manufacturing high-quality health functional supplements Joint development of products tailored specifically for the park golf market Activation of nationwide product distribution through Korea Park Golf’s sales channels Through this partnership, Mediance aims to expand its customer base and strengthen the competitiveness of its health supplement business. Both companies expect to create significant long-term synergy based on this strategic alliance.
Mediance Co., Ltd. has been officially selected for the Smart Logistics Platform Construction Project, led by the Korea Industrial Complex Corporation (KICOX). This national initiative aims to establish and operate an advanced smart logistics system within the Gangwon Hupyeong Smart Green Industrial Complex, and Mediance will receive KRW 5 billion in government support over the next three years (2025–2027). The project seeks to integrate and modernize logistics across Hupyeong Industrial Complex and neighboring clusters, ultimately enhancing logistics efficiency, reducing operational costs, and supporting high-level logistics innovation for regional enterprises. Based on this initiative, Mediance plans to build a future-oriented logistics environment through: Implementation of automated logistics facilities Establishment of an advanced smart logistics system Development of a data-driven, efficient logistics operation model A Mediance representative stated, “Being selected for the Smart Logistics Platform Project marks a significant milestone that will allow us to contribute to the innovation of the regional industrial ecosystem. We will accelerate our future growth by strengthening logistics competitiveness.” Mediance will continue to drive sustainable logistics innovation by leveraging advanced technologies and smart solutions, contributing to the development of regional industrial complexes while pursuing mutual growth with local businesses.
Mediance Selected for National Smart Logistics Platform Project… Secures KRW 5 Billion in Government FundingMediance Co., Ltd. has been officially selected for the Smart Logistics Platform Construction Project, led by the Korea Industrial Complex Corporation (KICOX). This national initiative aims to establish and operate an advanced smart logistics system within the Gangwon Hupyeong Smart Green Industrial Complex, and Mediance will receive KRW 5 billion in government support over the next three years (2025–2027). The project seeks to integrate and modernize logistics across Hupyeong Industrial Complex and neighboring clusters, ultimately enhancing logistics efficiency, reducing operational costs, and supporting high-level logistics innovation for regional enterprises. Based on this initiative, Mediance plans to build a future-oriented logistics environment through: Implementation of automated logistics facilities Establishment of an advanced smart logistics system Development of a data-driven, efficient logistics operation model A Mediance representative stated, “Being selected for the Smart Logistics Platform Project marks a significant milestone that will allow us to contribute to the innovation of the regional industrial ecosystem. We will accelerate our future growth by strengthening logistics competitiveness.” Mediance will continue to drive sustainable logistics innovation by leveraging advanced technologies and smart solutions, contributing to the development of regional industrial complexes while pursuing mutual growth with local businesses.
2025
Successful Clinical Trial for Eye Health Improvement2025
2024
Started Supplying Products to Home Shopping Channels2024
2023
Completion of Clinical Trial for Prostate Health Improvement2023
2023
KGMP and HACCP Certifications Acquired2023
2023
New Factory Construction in Namchuncheon Industrial Complex2023
The research team at Mediance Co., Ltd. has elucidated the core mechanism through which the transcription factor FOXO3a contributes to anti-aging effects and lifespan extension, and published its findings in the international peer-reviewed journal Biogerontology (IF 4.1, Top 25%). Using a genetically engineered mouse model designed to overexpress FOXO3a, the team demonstrated that FOXO3a regulates multiple biological processes, including enhanced DNA repair activity, reactive oxygen species removal, apoptosis regulation, stem cell activation, and autophagy induction. Additionally, the study confirmed that FOXO3a expression declines during aging, leading to decreased DNA repair capacity. Mechanistically, FOXO3a was shown to directly regulate DNA repair pathways at the transcriptional level. Importantly, in experiments exposing mice to high-dose gamma radiation (10 Gy), FOXO3a overexpression protected intestinal villus structure without adverse effects, reducing apoptosis and increasing both mean and maximum lifespan by approximately 30%. These findings indicate that FOXO3a plays a critical role in protecting cells against radiation-induced damage and improving survival outcomes. This study confirms that FOXO3a delays aging and promotes lifespan extension by enhancing DNA repair activity and regulating apoptosis. Based on this discovery, Mediance has initiated the development and screening of functional compounds that increase FOXO3a expression, with the goal of commercializing health functional supplements and pharmaceutical candidates targeting healthy longevity. Mediance aims to advance as a leader in aging science and longevity biotechnology, and will continue developing scientifically proven functional ingredients supported by rigorous research.
Mediance Identifies Key Mechanism of FOXO3a in Delaying Aging and Extending LifespanThe research team at Mediance Co., Ltd. has elucidated the core mechanism through which the transcription factor FOXO3a contributes to anti-aging effects and lifespan extension, and published its findings in the international peer-reviewed journal Biogerontology (IF 4.1, Top 25%). Using a genetically engineered mouse model designed to overexpress FOXO3a, the team demonstrated that FOXO3a regulates multiple biological processes, including enhanced DNA repair activity, reactive oxygen species removal, apoptosis regulation, stem cell activation, and autophagy induction. Additionally, the study confirmed that FOXO3a expression declines during aging, leading to decreased DNA repair capacity. Mechanistically, FOXO3a was shown to directly regulate DNA repair pathways at the transcriptional level. Importantly, in experiments exposing mice to high-dose gamma radiation (10 Gy), FOXO3a overexpression protected intestinal villus structure without adverse effects, reducing apoptosis and increasing both mean and maximum lifespan by approximately 30%. These findings indicate that FOXO3a plays a critical role in protecting cells against radiation-induced damage and improving survival outcomes. This study confirms that FOXO3a delays aging and promotes lifespan extension by enhancing DNA repair activity and regulating apoptosis. Based on this discovery, Mediance has initiated the development and screening of functional compounds that increase FOXO3a expression, with the goal of commercializing health functional supplements and pharmaceutical candidates targeting healthy longevity. Mediance aims to advance as a leader in aging science and longevity biotechnology, and will continue developing scientifically proven functional ingredients supported by rigorous research.
Biogerontology . 2025 Oct 28;26(6):196. doi: 10.1007/s10522-025-10341-9. FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse Gozde Inci 1 2, Madhuri Shende Warkad 1 2 3, Beom-Goo Kang 1, Sung-Ok Kim 1 2 3, Na-Kyung Lee 1, Jee-In Heo 1, Seong-Hoon Park 4, Jeong-Hyun Kim 1, Hong-Jun Kang 1, Chae-Ha Kim 1, Byung-Hak Kim 3, Sang-Jae Park 3, Jun Gyo Suh 5, Sung-Chan Kim 6 7, Soon Sung Lim 8, Jae-Yong Lee 9 10 11 Affiliations Expand PMID: 41148397 DOI: 10.1007/s10522-025-10341-9 Abstract To verify whether DNA repair is regulated by FOXO3a, a tet-on flag-h-FOXO3a transgenic mice were used. RT-q-PCR and western blot analysis showed that the mRNA and protein levels of flag-h-FOXO3a, XRCC4, XPC, APE1 and MSH2 increased dose dependently by doxycycline. DNA repair activities like non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR) also increased in a doxycycline dose dependent manner. MEF (mouse embryonic fibroblast) cells of the transgenic mouse were transfected with human XRCC4/XPC/APE1/MSH2 promoter-pGL3 basic vectors. Promoter assay and ChIP (chromatin immunoprecipitation) assay showed increased promoter activity and interactions of FOXO3a to FOXO consensus sites. The results indicate that XRCC4, XPC, APE1, and MSH2 are transcriptional target genes of FOXO3a and activities of NHEJ, NER, BER and MMR are regulated probably via transcriptional activation of XRCC4, XPC, APE1 and MSH2 by FOXO3a. FOXO3a overexpression in MEF cells and tet-on flag-h-FOXO3a transgenic mouse exhibited high resistance to gamma radiation. Small intestine showed less damage and apoptosis in doxycycline-treated mice. The median and maximum lifespan of the doxycycline-treated transgenic mice increased by about 30%. The results suggest that FOXO3a overexpression provide protection against gamma radiation and lifespan extension possibly via activation of DNA repair.
FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouseBiogerontology . 2025 Oct 28;26(6):196. doi: 10.1007/s10522-025-10341-9. FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse Gozde Inci 1 2, Madhuri Shende Warkad 1 2 3, Beom-Goo Kang 1, Sung-Ok Kim 1 2 3, Na-Kyung Lee 1, Jee-In Heo 1, Seong-Hoon Park 4, Jeong-Hyun Kim 1, Hong-Jun Kang 1, Chae-Ha Kim 1, Byung-Hak Kim 3, Sang-Jae Park 3, Jun Gyo Suh 5, Sung-Chan Kim 6 7, Soon Sung Lim 8, Jae-Yong Lee 9 10 11 Affiliations Expand PMID: 41148397 DOI: 10.1007/s10522-025-10341-9 Abstract To verify whether DNA repair is regulated by FOXO3a, a tet-on flag-h-FOXO3a transgenic mice were used. RT-q-PCR and western blot analysis showed that the mRNA and protein levels of flag-h-FOXO3a, XRCC4, XPC, APE1 and MSH2 increased dose dependently by doxycycline. DNA repair activities like non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR) also increased in a doxycycline dose dependent manner. MEF (mouse embryonic fibroblast) cells of the transgenic mouse were transfected with human XRCC4/XPC/APE1/MSH2 promoter-pGL3 basic vectors. Promoter assay and ChIP (chromatin immunoprecipitation) assay showed increased promoter activity and interactions of FOXO3a to FOXO consensus sites. The results indicate that XRCC4, XPC, APE1, and MSH2 are transcriptional target genes of FOXO3a and activities of NHEJ, NER, BER and MMR are regulated probably via transcriptional activation of XRCC4, XPC, APE1 and MSH2 by FOXO3a. FOXO3a overexpression in MEF cells and tet-on flag-h-FOXO3a transgenic mouse exhibited high resistance to gamma radiation. Small intestine showed less damage and apoptosis in doxycycline-treated mice. The median and maximum lifespan of the doxycycline-treated transgenic mice increased by about 30%. The results suggest that FOXO3a overexpression provide protection against gamma radiation and lifespan extension possibly via activation of DNA repair.
Mission & Vision
Mission
Vision
Core Value
R&D
Medience aims for sustainable health for humanity,
developing technologies with top-tier experts across various fields.
NATURAL EXTRACT
Medience performs extraction, concentration, separation, and purification of various natural sources to isolate active components. Through our premium functional dietary supplement brand, Dr's VIEW, we deliver these scientifically validated products to consumers with the highest quality standards.
FLAVONOID EXTRACTION
Flavonoids, found in most plants, have antioxidant effects and diverse bioactivities, contributing to the rapid growth of the global functional ingredient market. Medience leads this field by applying advanced analysis, production, separation, and purification techniques to develop premium functional ingredients.
FERMENTATION TECHNOLOGY
Fermentation promotes the production of beneficial compounds through microorganisms while reducing harmful substances. Demand is also growing for products designed to improve metabolism and enhance bioavailability. Medience owns proprietary Korean Lactobacillus sp. strains and produces high-efficiency GABA-rich fermented materials, applying them across diverse biotransformation processes.
COMMERCIALIZATION SERVICES
Medience provides A-to-Z commercialization services for individually recognized ingredients with proven functionality, based on 24 years of R&D expertise. Our services cover marker compound development, analysis, process establishment, scale-up, economic analysis, clinical trials, patent and stability asset protection, ensuring competitive and high-value product development.
ENGINEERING
With over 24 years of accumulated expertise in food-related R&D, process development, and plant construction, Medience offers comprehensive engineering solutions for the development of health functional food production processes and facility construction. Process efficiency is a critical factor in the success of any manufacturing plant. We possess extensive experience in developing production processes and constructing factories for diverse materials such as Y-PEP (egg yolk lecithin), AGK (Angelica gigas Nakai extract), ISD (herbal extracts), and other natural sources.
Partnership
History
For Humanity, Medience Continues to Move Forward
2025 | Successful Clinical Trial of Eye Health Ingredient |
| Government Logistics Project with Korea Industrial Complex Corporation | |
| Successful Clinical Trial of Growth-Enhancing Ingredient |
2024 | 03 | Acquired HACCP certification for general foods (fruit and vegetable juices) Launched product sales through home shopping channels |
04 | Exported finished products to China | |
12 | Application for health functional ingredient to improve prostate health |
2023 | 04 | Completed construction of the new factory in the Namchuncheon Industrial Complex |
05 | Selected as a Bio Star Company by the Chuncheon Bioindustry Foundation | |
06 | Increased capital Secured foreign investment from Japan | |
08 | Increased capital | |
09 | Acquired HACCP certification for general foods(candy and snack categories) | |
09 | Start clinical trial for height growth | |
11 | Start clinical trial for eye health |
2022 | 01 | Designated as a Promising Export SME Increased capital |
01 | Secured domestic investment | |
02 | Start clinical trial for prostate health | |
04 | Began construction of a new factory in the Namchuncheon Industrial Complex (KGMP, HACCP certified) | |
09 | Increased capital | |
09 | Secured foreign investment from
the United States |
2021 | 04 | Secured foreign investment from the United States |
05 | Acquired GMP certification for medical devices | |
08 | Increased capital | |
08 | Awarded a commendation from the Korea SMEs and Startups Agency | |
12 | Awarded a commendation from the Minister of
Trade, Industry and Energy |
2020 | 03 | Began supplying NMN products to China |
04 | Registered a patent for the NO Activator, which is an anti-metastatic anticancer agent | |
12 | Obtained hygiene permits in Vietnam for NO Allium and NK Active |
2019 | 01 | Awarded the Best Management Evaluation Company by the Chuncheon Bioindustry Foundation |
02 | Completed tenancy agreement in Namchuncheon Industrial Complex | |
| 06 | Certified as a Technology-Innovative SME (Inno-Biz)
Expanded finished product production lines, and acquired
GMP certification for functional dietary supplements | |
| 07 | Increased capital | |
| 10 | Certified as a Promising SME in Gangwon-do | |
| 12 | Received commendations from the Mayor of
Chuncheon-si and the Governor of Gangwon-do
Designated as a Promising Export SME |
2018 | 05 | Certified as a Gangwon Global IP Star Company |
12 | Received Intellectual Property Management Certification for SMEs Awarded the Gangwon SME Grand Prize by the Administrator of the Small and Medium Business Administration |
2017 | 06 | Selected for preclinical trial projects (focused on bone density improvement and menopause), and conducted clinical trials for immune enhancement |
09 | Certified as a Gangwon Bio Star Company | |
11 | Certified as a Promising Export SME | |
| 12 | Received the Prime Minister’s Commendation and the
Gangwon Governor’s Commendation |
2016 | 04 | Approved for a Class III Medical Device Clinical Trial |
05 | Selected for the Production Technology Commercialization Support Project | |
10 | Selected for the Economic Cooperation Zone Industry Promotion Project | |
| 12 | Increased capital |
2015 | 05 | Selected for the Regional Strategic Technology Development Promotion Project |
06 | Selected for the Product Process Technology Development Project | |
11 | Certified as a Promising Export SME |
2014 | 04 | Registered Medience Co., Ltd. Second Factory, and received certification for its company-affiliated research institute |
05 | Obtained feed manufacturing license, and selected for the Small and Medium Business Administration’s Nano Calcium Project | |
07 | Selected for the Regional Specialization Technology Development Promotion Project | |
| 12 | Acquired food additive manufacturing license,
and increased capital |
2013 | 02 | Established Medience Co., Ltd. |
03 | Acquired food manufacturing license | |
04 | Registered Medience Co., Ltd. First Factory Obtained specialized manufacturing license for functional dietary supplements | |
| 10 | Certified as a venture company | |
| 11 | Selected for On-Site Technology Development Project |
Contents
For sustainable health, Medience is opening the future at this very moment
Mediance Co., Ltd. participated as an official sponsor of the 2025 Uiseong Cheonhajangsa Ssireum Festival, held from November 23 to 29, 2025, by providing its proprietary cognitive health supplement, Tteoolla AO300. Tteoolla AO300 is a functional health supplement designed to support cognitive enhancement, featuring a distinctive double-formula structure that combines ingredients known to help improve memory with premium Korean red ginseng. The product also supports immune function, making it suitable for a wide range of consumers. Through this sponsorship, Mediance aimed to highlight the scientific excellence and brand value of Tteoolla AO300, while providing healthy energy to the athletes and spectators participating in the festival. Mediance will continue to expand its brand presence by engaging in various sports and community activities, reinforcing the company’s commitment to enhancing customer well-being and delivering high-quality health functional products.
Mediance Sponsors “2025 Uiseong Cheonhajangsa Ssireum Festival” with Tteoolla AO300Mediance Co., Ltd. participated as an official sponsor of the 2025 Uiseong Cheonhajangsa Ssireum Festival, held from November 23 to 29, 2025, by providing its proprietary cognitive health supplement, Tteoolla AO300. Tteoolla AO300 is a functional health supplement designed to support cognitive enhancement, featuring a distinctive double-formula structure that combines ingredients known to help improve memory with premium Korean red ginseng. The product also supports immune function, making it suitable for a wide range of consumers. Through this sponsorship, Mediance aimed to highlight the scientific excellence and brand value of Tteoolla AO300, while providing healthy energy to the athletes and spectators participating in the festival. Mediance will continue to expand its brand presence by engaging in various sports and community activities, reinforcing the company’s commitment to enhancing customer well-being and delivering high-quality health functional products.
Mediance Co., Ltd. has recently signed a Memorandum of Understanding (MOU) with Korea Park Golf Co., Ltd. to jointly promote the sales of health supplements. Korea Park Golf is a leading company in the domestic park golf industry, holding approximately 70% market share and operating a strong nationwide network of dealerships and infrastructure. Through this agreement, the two companies will establish a strategic collaboration in which Mediance develops and manufactures health functional products, while Korea Park Golf utilizes its distribution channels to deliver them to market. Under this MOU, the two companies plan to pursue various forms of cooperation, including: Planning and manufacturing high-quality health functional supplements Joint development of products tailored specifically for the park golf market Activation of nationwide product distribution through Korea Park Golf’s sales channels Through this partnership, Mediance aims to expand its customer base and strengthen the competitiveness of its health supplement business. Both companies expect to create significant long-term synergy based on this strategic alliance.
Mediance Signs MOU with Korea Park Golf Co., Ltd. for Health Supplement Sales CollaborationMediance Co., Ltd. has recently signed a Memorandum of Understanding (MOU) with Korea Park Golf Co., Ltd. to jointly promote the sales of health supplements. Korea Park Golf is a leading company in the domestic park golf industry, holding approximately 70% market share and operating a strong nationwide network of dealerships and infrastructure. Through this agreement, the two companies will establish a strategic collaboration in which Mediance develops and manufactures health functional products, while Korea Park Golf utilizes its distribution channels to deliver them to market. Under this MOU, the two companies plan to pursue various forms of cooperation, including: Planning and manufacturing high-quality health functional supplements Joint development of products tailored specifically for the park golf market Activation of nationwide product distribution through Korea Park Golf’s sales channels Through this partnership, Mediance aims to expand its customer base and strengthen the competitiveness of its health supplement business. Both companies expect to create significant long-term synergy based on this strategic alliance.
Mediance Co., Ltd. has been officially selected for the Smart Logistics Platform Construction Project, led by the Korea Industrial Complex Corporation (KICOX). This national initiative aims to establish and operate an advanced smart logistics system within the Gangwon Hupyeong Smart Green Industrial Complex, and Mediance will receive KRW 5 billion in government support over the next three years (2025–2027). The project seeks to integrate and modernize logistics across Hupyeong Industrial Complex and neighboring clusters, ultimately enhancing logistics efficiency, reducing operational costs, and supporting high-level logistics innovation for regional enterprises. Based on this initiative, Mediance plans to build a future-oriented logistics environment through: Implementation of automated logistics facilities Establishment of an advanced smart logistics system Development of a data-driven, efficient logistics operation model A Mediance representative stated, “Being selected for the Smart Logistics Platform Project marks a significant milestone that will allow us to contribute to the innovation of the regional industrial ecosystem. We will accelerate our future growth by strengthening logistics competitiveness.” Mediance will continue to drive sustainable logistics innovation by leveraging advanced technologies and smart solutions, contributing to the development of regional industrial complexes while pursuing mutual growth with local businesses.
Mediance Selected for National Smart Logistics Platform Project… Secures KRW 5 Billion in Government FundingMediance Co., Ltd. has been officially selected for the Smart Logistics Platform Construction Project, led by the Korea Industrial Complex Corporation (KICOX). This national initiative aims to establish and operate an advanced smart logistics system within the Gangwon Hupyeong Smart Green Industrial Complex, and Mediance will receive KRW 5 billion in government support over the next three years (2025–2027). The project seeks to integrate and modernize logistics across Hupyeong Industrial Complex and neighboring clusters, ultimately enhancing logistics efficiency, reducing operational costs, and supporting high-level logistics innovation for regional enterprises. Based on this initiative, Mediance plans to build a future-oriented logistics environment through: Implementation of automated logistics facilities Establishment of an advanced smart logistics system Development of a data-driven, efficient logistics operation model A Mediance representative stated, “Being selected for the Smart Logistics Platform Project marks a significant milestone that will allow us to contribute to the innovation of the regional industrial ecosystem. We will accelerate our future growth by strengthening logistics competitiveness.” Mediance will continue to drive sustainable logistics innovation by leveraging advanced technologies and smart solutions, contributing to the development of regional industrial complexes while pursuing mutual growth with local businesses.
2025
Successful Clinical Trial for Eye Health Improvement2025
2024
Started Supplying Products to Home Shopping Channels2024
2023
Completion of Clinical Trial for Prostate Health Improvement2023
2023
KGMP and HACCP Certifications Acquired2023
2023
New Factory Construction in Namchuncheon Industrial Complex2023
The research team at Mediance Co., Ltd. has elucidated the core mechanism through which the transcription factor FOXO3a contributes to anti-aging effects and lifespan extension, and published its findings in the international peer-reviewed journal Biogerontology (IF 4.1, Top 25%). Using a genetically engineered mouse model designed to overexpress FOXO3a, the team demonstrated that FOXO3a regulates multiple biological processes, including enhanced DNA repair activity, reactive oxygen species removal, apoptosis regulation, stem cell activation, and autophagy induction. Additionally, the study confirmed that FOXO3a expression declines during aging, leading to decreased DNA repair capacity. Mechanistically, FOXO3a was shown to directly regulate DNA repair pathways at the transcriptional level. Importantly, in experiments exposing mice to high-dose gamma radiation (10 Gy), FOXO3a overexpression protected intestinal villus structure without adverse effects, reducing apoptosis and increasing both mean and maximum lifespan by approximately 30%. These findings indicate that FOXO3a plays a critical role in protecting cells against radiation-induced damage and improving survival outcomes. This study confirms that FOXO3a delays aging and promotes lifespan extension by enhancing DNA repair activity and regulating apoptosis. Based on this discovery, Mediance has initiated the development and screening of functional compounds that increase FOXO3a expression, with the goal of commercializing health functional supplements and pharmaceutical candidates targeting healthy longevity. Mediance aims to advance as a leader in aging science and longevity biotechnology, and will continue developing scientifically proven functional ingredients supported by rigorous research.
Mediance Identifies Key Mechanism of FOXO3a in Delaying Aging and Extending LifespanThe research team at Mediance Co., Ltd. has elucidated the core mechanism through which the transcription factor FOXO3a contributes to anti-aging effects and lifespan extension, and published its findings in the international peer-reviewed journal Biogerontology (IF 4.1, Top 25%). Using a genetically engineered mouse model designed to overexpress FOXO3a, the team demonstrated that FOXO3a regulates multiple biological processes, including enhanced DNA repair activity, reactive oxygen species removal, apoptosis regulation, stem cell activation, and autophagy induction. Additionally, the study confirmed that FOXO3a expression declines during aging, leading to decreased DNA repair capacity. Mechanistically, FOXO3a was shown to directly regulate DNA repair pathways at the transcriptional level. Importantly, in experiments exposing mice to high-dose gamma radiation (10 Gy), FOXO3a overexpression protected intestinal villus structure without adverse effects, reducing apoptosis and increasing both mean and maximum lifespan by approximately 30%. These findings indicate that FOXO3a plays a critical role in protecting cells against radiation-induced damage and improving survival outcomes. This study confirms that FOXO3a delays aging and promotes lifespan extension by enhancing DNA repair activity and regulating apoptosis. Based on this discovery, Mediance has initiated the development and screening of functional compounds that increase FOXO3a expression, with the goal of commercializing health functional supplements and pharmaceutical candidates targeting healthy longevity. Mediance aims to advance as a leader in aging science and longevity biotechnology, and will continue developing scientifically proven functional ingredients supported by rigorous research.
Biogerontology . 2025 Oct 28;26(6):196. doi: 10.1007/s10522-025-10341-9. FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse Gozde Inci 1 2, Madhuri Shende Warkad 1 2 3, Beom-Goo Kang 1, Sung-Ok Kim 1 2 3, Na-Kyung Lee 1, Jee-In Heo 1, Seong-Hoon Park 4, Jeong-Hyun Kim 1, Hong-Jun Kang 1, Chae-Ha Kim 1, Byung-Hak Kim 3, Sang-Jae Park 3, Jun Gyo Suh 5, Sung-Chan Kim 6 7, Soon Sung Lim 8, Jae-Yong Lee 9 10 11 Affiliations Expand PMID: 41148397 DOI: 10.1007/s10522-025-10341-9 Abstract To verify whether DNA repair is regulated by FOXO3a, a tet-on flag-h-FOXO3a transgenic mice were used. RT-q-PCR and western blot analysis showed that the mRNA and protein levels of flag-h-FOXO3a, XRCC4, XPC, APE1 and MSH2 increased dose dependently by doxycycline. DNA repair activities like non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR) also increased in a doxycycline dose dependent manner. MEF (mouse embryonic fibroblast) cells of the transgenic mouse were transfected with human XRCC4/XPC/APE1/MSH2 promoter-pGL3 basic vectors. Promoter assay and ChIP (chromatin immunoprecipitation) assay showed increased promoter activity and interactions of FOXO3a to FOXO consensus sites. The results indicate that XRCC4, XPC, APE1, and MSH2 are transcriptional target genes of FOXO3a and activities of NHEJ, NER, BER and MMR are regulated probably via transcriptional activation of XRCC4, XPC, APE1 and MSH2 by FOXO3a. FOXO3a overexpression in MEF cells and tet-on flag-h-FOXO3a transgenic mouse exhibited high resistance to gamma radiation. Small intestine showed less damage and apoptosis in doxycycline-treated mice. The median and maximum lifespan of the doxycycline-treated transgenic mice increased by about 30%. The results suggest that FOXO3a overexpression provide protection against gamma radiation and lifespan extension possibly via activation of DNA repair.
FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouseBiogerontology . 2025 Oct 28;26(6):196. doi: 10.1007/s10522-025-10341-9. FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse Gozde Inci 1 2, Madhuri Shende Warkad 1 2 3, Beom-Goo Kang 1, Sung-Ok Kim 1 2 3, Na-Kyung Lee 1, Jee-In Heo 1, Seong-Hoon Park 4, Jeong-Hyun Kim 1, Hong-Jun Kang 1, Chae-Ha Kim 1, Byung-Hak Kim 3, Sang-Jae Park 3, Jun Gyo Suh 5, Sung-Chan Kim 6 7, Soon Sung Lim 8, Jae-Yong Lee 9 10 11 Affiliations Expand PMID: 41148397 DOI: 10.1007/s10522-025-10341-9 Abstract To verify whether DNA repair is regulated by FOXO3a, a tet-on flag-h-FOXO3a transgenic mice were used. RT-q-PCR and western blot analysis showed that the mRNA and protein levels of flag-h-FOXO3a, XRCC4, XPC, APE1 and MSH2 increased dose dependently by doxycycline. DNA repair activities like non-homologous end joining (NHEJ), nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR) also increased in a doxycycline dose dependent manner. MEF (mouse embryonic fibroblast) cells of the transgenic mouse were transfected with human XRCC4/XPC/APE1/MSH2 promoter-pGL3 basic vectors. Promoter assay and ChIP (chromatin immunoprecipitation) assay showed increased promoter activity and interactions of FOXO3a to FOXO consensus sites. The results indicate that XRCC4, XPC, APE1, and MSH2 are transcriptional target genes of FOXO3a and activities of NHEJ, NER, BER and MMR are regulated probably via transcriptional activation of XRCC4, XPC, APE1 and MSH2 by FOXO3a. FOXO3a overexpression in MEF cells and tet-on flag-h-FOXO3a transgenic mouse exhibited high resistance to gamma radiation. Small intestine showed less damage and apoptosis in doxycycline-treated mice. The median and maximum lifespan of the doxycycline-treated transgenic mice increased by about 30%. The results suggest that FOXO3a overexpression provide protection against gamma radiation and lifespan extension possibly via activation of DNA repair.
